Affinity capillary electrophoresis - mass spectrometry permits direct binding assessment of IgG and FcÎ³RIIa in a glycoform-resolved manner.

Gstöttner, Christoph; Knaupp, Alexander; Vidarsson, Gestur; Reusch, Dietmar; Schlothauer, Tilman; Wuhrer, Manfred; Domínguez-Vega, Elena

Gstöttner, Christoph; Knaupp, Alexander; Vidarsson, Gestur; Reusch, Dietmar; Schlothauer, Tilman; Wuhrer, Manfred; Domínguez-Vega, Elena.

Afiliação

Gstöttner C; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, Netherlands.
Knaupp A; Pharma Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
Vidarsson G; Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Reusch D; Pharma Technical Development Penzberg, Roche Diagnostics GmbH, Penzberg, Germany.
Schlothauer T; Pharma Research and Early Development, Roche Innovation Center Munich, Munich, Germany.
Wuhrer M; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, Netherlands.
Domínguez-Vega E; Leiden University Medical Center, Center for Proteomics and Metabolomics, Leiden, Netherlands.

Front Immunol ; 13: 980291, 2022.

Article em En | MEDLINE | ID: mdl-36159782

Assuntos

Imunoglobulina G; Receptores de IgG; Eletroforese Capilar; Imunoglobulina G/metabolismo; Espectrometria de Massas; Polissacarídeos/metabolismo; Receptores de IgG/metabolismo

Palavras-chave

FcÎ³RIIa receptor; affinity capillary electrophoresis (ACE); glycosylation; interaction; mass spectrometry; monoclonal antibody

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imunoglobulina G / Receptores de IgG Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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