Housebreaking Plasmodium parasites leave their fingerprints at the door.

Bardtke, Lara; Cockburn, Ian A

Bardtke, Lara; Cockburn, Ian A.

Afiliação

Bardtke L; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Augustenburger Platz 1, 13353 Berlin, Germany; Division of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia.
Cockburn IA; Division of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia. Electronic address: ian.cockburn@anu.edu.au.

Trends Parasitol ; 38(11): 921-923, 2022 11.

Article em En | MEDLINE | ID: mdl-36163104

ABSTRACT

ABSTRACT

Protective antibodies against Plasmodium falciparum merozoite antigens, including EBA-175, can inhibit erythrocyte invasion. New data from Musasia et al. indicate that these antibodies can also trigger antibody-dependent phagocytosis of ring-infected and uninfected erythrocytes and that this correlates with protection from malaria. This provides a new pathway for vaccine design.

Assuntos

Vacinas Antimaláricas; Malária Falciparum; Parasitos; Animais; Anticorpos Antiprotozoários; Antígenos de Protozoários; Eritrócitos/parasitologia; Malária Falciparum/parasitologia; Plasmodium falciparum; Proteínas de Protozoários/metabolismo

Palavras-chave

EBA-175; Plasmodium; blood stages; cytophilic antibodies; malaria; phagocytosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Parasitos / Malária Falciparum / Vacinas Antimaláricas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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