[Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway].

Wu, Li-Min; Zhao, Jie; Zhang, Xiao-Wei; Li, Zhong-Hua; Wang, Pan; Sun, Yi-Ran; Zhang, Zhen-Qiang; Xie, Zhi-Shen

Wu, Li-Min; Zhao, Jie; Zhang, Xiao-Wei; Li, Zhong-Hua; Wang, Pan; Sun, Yi-Ran; Zhang, Zhen-Qiang; Xie, Zhi-Shen.

Afiliação

Wu LM; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China Pharmacy College, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Zhao J; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Zhang XW; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Li ZH; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Wang P; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Sun YR; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Zhang ZQ; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.
Xie ZS; Academy of Chinese Medical Sciences, Henan University of Traditional Chinese Medicine Zhengzhou 450046,China.

Zhongguo Zhong Yao Za Zhi ; 47(17): 4723-4732, 2022 Sep.

Article em Zh | MEDLINE | ID: mdl-36164880

Assuntos

Doença de Alzheimer; Atractylodes; Autofagia; Proteínas Quinases Ativadas por AMP/genética; Proteínas Quinases Ativadas por AMP/metabolismo; Doença de Alzheimer/tratamento farmacológico; Peptídeos beta-Amiloides/genética; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Atractylodes/química; Autofagia/efeitos dos fármacos; Proteína Beclina-1/farmacologia; Caenorhabditis elegans/genética; Caenorhabditis elegans/metabolismo; Macroautofagia; Camundongos; RNA Mensageiro; Sirolimo/farmacologia

Palavras-chave

Alzheimer's disease; Atractylodes macrocephala; LKB1-AMPK-TFEB; lysophagy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Atractylodes / Doença de Alzheimer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: Zh Ano de publicação: 2022 Tipo de documento: Article

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