Regioselective peri-C-H selenylation of aromatic compounds with weakly coordinating ketone groups.
Chem Commun (Camb)
; 58(82): 11555-11558, 2022 Oct 13.
Article
em En
| MEDLINE
| ID: mdl-36165048
ABSTRACT
A novel and versatile method for peri-C-H selenylation of aromatic compounds bearing ketone groups, including chromones, xanthones, acridinones, quinolinones and naphthoquinones with diselenides under Ru(II) catalysis is presented. Various chromones and diselenides are applicable for this transformation, affording 5-selenyl chromones in a highly regioselective manner in good to excellent yields. This transformation is easy to scale up and the desired products can be further modified. Most importantly, this transformation allows the late-stage selenylation of bioactive compounds. Mechanistic studies show that radicals may be involved in this novel transformation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
/
Quinolonas
/
Xantonas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article