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Recent advances in the screening methods of NPC1L1 inhibitors.
Zhang, Renshuai; Liu, Wenjing; Zeng, Jun; Meng, Jingsen; Shi, Lingyu; Yang, Shanbo; Chang, Jing; Wang, Chao; Xing, Kunyue; Wen, Jialian; Liu, Ning; Liang, Bing; Xing, Dongming.
Afiliação
  • Zhang R; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Liu W; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Zeng J; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Meng J; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Shi L; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Yang S; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Chang J; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Wang C; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China.
  • Xing K; Alliance Manchester Business School, The University of Manchester, Manchester, UK.
  • Wen J; School of Social Science, The University of Manchester, Manchester, UK. Electronic address: jialian.wen@student.manchester.ac.uk.
  • Liu N; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China. Electronic address: leirum_ln@qdu.edu.cn.
  • Liang B; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China. Electronic address: liangbing@qdu.edu.cn.
  • Xing D; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, School of Basic Medicine of Qingdao University, Qingdao, China; Qingdao Cancer Institute, Qingdao, China; School of Life Sciences, Tsinghua University, Beijing, China. Electronic address: xdm@qdu.edu.cn.
Biomed Pharmacother ; 155: 113732, 2022 Nov.
Article em En | MEDLINE | ID: mdl-36166964
ABSTRACT
NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant risk factor for cardiovascular diseases such as coronary heart disease. Screening of NPC1L1 inhibitors is critical for gaining a full understanding of lipid metabolism, developing new cholesterol-lowering medicines, and treating cardiovascular diseases. This work summarized existing methodologies for screening NPC1L1 inhibitors and evaluated their challenges, and will assist the development of novel cholesterol-lowering medications and therapeutic strategies for hypercholesterolemia and other cholesterol-related metabolic disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Hipercolesterolemia / Anticolesterolemiantes Tipo de estudo: Diagnostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Hipercolesterolemia / Anticolesterolemiantes Tipo de estudo: Diagnostic_studies / Risk_factors_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article