Exploring the molecular and functional cellular response to hydrazine via transcriptomics and DNA repair mutant cell lines.

Crosby, Meredith E; Ciurlionis, Rita; Brayman, Timothy G; Kondratiuk, Alison; Nicolette, John J

Crosby, Meredith E; Ciurlionis, Rita; Brayman, Timothy G; Kondratiuk, Alison; Nicolette, John J.

Afiliação

Crosby ME; Pre-Clinical Safety, AbbVie Inc., North Chicago, Illinois, United States.
Ciurlionis R; Drug Safety and Pharmacometrics, Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States.
Brayman TG; Pre-Clinical Safety, AbbVie Inc., North Chicago, Illinois, United States.
Kondratiuk A; Pre-Clinical Safety, AbbVie Inc., North Chicago, Illinois, United States.
Nicolette JJ; Pre-Clinical Safety, AbbVie Inc., North Chicago, Illinois, United States.

Environ Mol Mutagen ; 63(7): 336-350, 2022 08.

Article em En | MEDLINE | ID: mdl-36176055

Assuntos

Reparo do DNA; Transcriptoma; Humanos; Camundongos; Animais; Transcriptoma/genética; Reparo do DNA/genética; Dano ao DNA; Mutagênicos/toxicidade; Linhagem Celular; Carcinógenos/toxicidade; Hidrazinas/toxicidade

Palavras-chave

DNA repair pathways; clonogenic assay; differentially expressed genes; hprt assay; hydrazine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reparo do DNA / Transcriptoma Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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