Proteome Integral Solubility Alteration (PISA) for High-Throughput Ligand Target Deconvolution with Increased Statistical Significance and Reduced Sample Amount.

Gaetani, Massimiliano; Zubarev, Roman A

Gaetani, Massimiliano; Zubarev, Roman A.

Afiliação

Gaetani M; Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. massimiliano.gaetani@ki.se.
Zubarev RA; Chemical Proteomics Core Facility, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. massimiliano.gaetani@ki.se.

Methods Mol Biol ; 2554: 91-106, 2023.

Article em En | MEDLINE | ID: mdl-36178622

Assuntos

Proteoma; Proteômica; Ligantes; Espectrometria de Massas; Proteoma/metabolismo; Proteômica/métodos; Solubilidade

Palavras-chave

Chemoproteomics; Ligand; Ligand target deconvolution; PISA; Proteinmetabolite interactions; Solubility alteration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteoma / Proteômica Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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