Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis.

Takeda, David Y; Sowalsky, Adam G

Takeda, David Y; Sowalsky, Adam G.

Afiliação

Takeda DY; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.
Sowalsky AG; Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA. Electronic address: adam.sowalsky@nih.gov.

Cancer Cell ; 40(10): 1086-1088, 2022 10 10.

Article em En | MEDLINE | ID: mdl-36179684

ABSTRACT

ABSTRACT

Prostate cancer (PCa) frequently metastasizes to bone, and analyses of DNA from bone biopsies are exceptionally challenging. A recent report in Nature demonstrates that whole-genome sequencing (WGS) of circulating tumor DNA (ctDNA) from patients with metastatic PCa can inform on the subclonal composition of metastatic disease and infer patterns of gene expression.

Assuntos

DNA Tumoral Circulante; Neoplasias da Próstata; Biologia; Biomarcadores Tumorais/genética; DNA Tumoral Circulante/genética; Humanos; Masculino; Mutação; Metástase Neoplásica; Neoplasias da Próstata/genética; Neoplasias da Próstata/patologia; Sequenciamento Completo do Genoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / DNA Tumoral Circulante Limite: Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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