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Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice.
Melzi, Eleonora; Willis, Jordan R; Ma, Krystal M; Lin, Ying-Cing; Kratochvil, Sven; Berndsen, Zachary T; Landais, Elise A; Kalyuzhniy, Oleksandr; Nair, Usha; Warner, John; Steichen, Jon M; Kalyuzhniy, Anton; Le, Amber; Pecetta, Simone; Perez, Manfredo; Kirsch, Kathrin; Weldon, Stephanie R; Falcone, Samantha; Himansu, Sunny; Carfi, Andrea; Sok, Devin; Ward, Andrew B; Schief, William R; Batista, Facundo D.
Afiliação
  • Melzi E; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Willis JR; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Ma KM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Lin YC; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Kratochvil S; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Berndsen ZT; Department of Integrative, Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Landais EA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Kalyuzhniy O; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Nair U; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Warner J; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Steichen JM; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Kalyuzhniy A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Le A; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Pecetta S; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Perez M; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Kirsch K; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Weldon SR; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Falcone S; Moderna Inc., Cambridge, MA 02139, USA.
  • Himansu S; Moderna Inc., Cambridge, MA 02139, USA.
  • Carfi A; Moderna Inc., Cambridge, MA 02139, USA.
  • Sok D; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Res
  • Ward AB; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative, Structural and Computational Bi
  • Schief WR; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037, USA; International AIDS Vaccine Initiative Neutralizing Antibody Center, the Collaboration for AIDS Vaccine Discovery (CAVD) and Scrip
  • Batista FD; The Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Immunology, Harvard Medical School, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA. Electronic address: fbatista1@mgh.harvard.edu.
Immunity ; 55(11): 2168-2186.e6, 2022 11 08.
Article em En | MEDLINE | ID: mdl-36179690
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Vacinas contra a AIDS Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / HIV-1 / Vacinas contra a AIDS Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article