Treatment with cyclophosphamide in post-weaning mice causes prolonged suppression of neural stem cell proliferation in the hippocampal dentate gyrus.
Brain Res
; 1796: 148108, 2022 12 01.
Article
em En
| MEDLINE
| ID: mdl-36181781
ABSTRACT
The effects of anticancer drugs used in childhood on brain function in adulthood are unclear. Here, we report the long-term changes in the proliferation of neuronal stem/progenitor cells (NPCs) in the hippocampal dentate gyrus after treatment with cyclophosphamide (CYP), which is often used as a therapeutic medicine in childhood cancer. A systemic injection of CYP into 3-week-old mice decreased 5-bromo-2'-deoxyuridine (BrdU)-incorporated cells in the hippocampal subgranular zone 2 and 55 days after the injection in a dose-dependent manner. Restraint stress induced increase in corticosterone level, which was enhanced by CYP at day 35 after injection. These findings suggest that CYP injection into post-weaning mice causes prolonged alteration in NPC proliferation in the hippocampus and the stress response.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Giro Denteado
/
Células-Tronco Neurais
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article