Complementary CRISPR genome-wide genetic screens in PARP10-knockout and overexpressing cells identify synthetic interactions for PARP10-mediated cellular survival.

Khatib, Jude B; Schleicher, Emily M; Jackson, Lindsey M; Dhoonmoon, Ashna; Moldovan, George-Lucian; Nicolae, Claudia M

Khatib, Jude B; Schleicher, Emily M; Jackson, Lindsey M; Dhoonmoon, Ashna; Moldovan, George-Lucian; Nicolae, Claudia M.

Afiliação

Khatib JB; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Schleicher EM; These authors contributed equally to this work.
Jackson LM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Dhoonmoon A; These authors contributed equally to this work.
Moldovan GL; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Nicolae CM; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.

Oncotarget ; 13: 1078-1091, 2022.

Article em En | MEDLINE | ID: mdl-36187556

Assuntos

Neoplasias; Poli(ADP-Ribose) Polimerases; ADP Ribose Transferases/genética; Repetições Palindrômicas Curtas Agrupadas e Regularmente Espaçadas; DNA; Humanos; Neoplasias/genética; Poli(ADP-Ribose) Polimerases/genética; Poli(ADP-Ribose) Polimerases/metabolismo; Medicina de Precisão; Proteínas Proto-Oncogênicas/genética

Palavras-chave

ATM; CRISPR screens; PARP10; cancer cell proliferation; genome stability

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poli(ADP-Ribose) Polimerases / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google