Exploring the Potential of Multinuclear Solid-State 1 H, 13 C, and 35 Cl Magnetic Resonance To Characterize Static and Dynamic Disorder in Pharmaceutical Hydrochlorides.

Szell, Patrick M J; Rehman, Zainab; Tatman, Ben P; Hughes, Leslie P; Blade, Helen; Brown, Steven P

Exploring the Potential of Multinuclear Solid-State ¹ H, ¹³ C, and ³⁵ Cl Magnetic Resonance To Characterize Static and Dynamic Disorder in Pharmaceutical Hydrochlorides.

Szell, Patrick M J; Rehman, Zainab; Tatman, Ben P; Hughes, Leslie P; Blade, Helen; Brown, Steven P.

Afiliação

Szell PMJ; Department of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Rehman Z; Department of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Tatman BP; Department of Physics, University of Warwick, Coventry, CV4 7AL, UK.
Hughes LP; Oral Product Development Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, SK10 2NA, UK.
Blade H; Oral Product Development Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, SK10 2NA, UK.
Brown SP; Department of Physics, University of Warwick, Coventry, CV4 7AL, UK.

Chemphyschem ; 24(3): e202200558, 2023 02 01.

Article em En | MEDLINE | ID: mdl-36195553

Assuntos

Cloretos; Imageamento por Ressonância Magnética; Humanos; Espectroscopia de Ressonância Magnética/métodos; Preparações Farmacêuticas

Palavras-chave

NMR; X-ray crystallography; crystallographic disorder; density functional theory; pharmaceuticals

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Cloretos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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