Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.

Williams, Jessica S; Wojtaszek, Jessica L; Appel, Denise C; Krahn, Juno; Wallace, Bret D; Walsh, Evan; Kunkel, Thomas A; Williams, R Scott

Williams, Jessica S; Wojtaszek, Jessica L; Appel, Denise C; Krahn, Juno; Wallace, Bret D; Walsh, Evan; Kunkel, Thomas A; Williams, R Scott.

Afiliação

Williams JS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Wojtaszek JL; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Appel DC; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Krahn J; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Wallace BD; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Walsh E; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Kunkel TA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: kunkel@niehs.nih.gov.
Williams RS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: williamsrs@niehs.nih.gov.

Cell Rep ; 41(1): 111448, 2022 10 04.

Article em En | MEDLINE | ID: mdl-36198268

Assuntos

Proteínas de Saccharomyces cerevisiae; DNA; Dano ao DNA; DNA Polimerase II/genética; Reparo do DNA; DNA Topoisomerases Tipo I/metabolismo; DNA Liase (Sítios Apurínicos ou Apirimidínicos)/genética; Ribonucleotídeos/química; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo

Palavras-chave

APE2; Apn2; CP: molecular biology; DNA damage; DNA repair; DNA replication; S. cerevisiae; Top1; X-ray crystallography; ribonucleotide

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Saccharomyces cerevisiae Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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