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Prevalence of potentially inappropriate prescribing in older adults in Central and Eastern Europe: a systematic review and synthesis without meta-analysis.
Brkic, Jovana; Fialova, Daniela; Okuyan, Betul; Kummer, Ingrid; Sesto, Sofija; Capiau, Andreas; Hadziabdic, Maja Ortner; Tachkov, Konstantin; Bobrova, Veera.
Afiliação
  • Brkic J; Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, 500 05, Czech Republic. jovanabrkic37@gmail.com.
  • Fialova D; Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, 500 05, Czech Republic.
  • Okuyan B; Department of Geriatrics and Gerontology, First Faculty of Medicine, Charles University, Prague, 121 08, Czech Republic.
  • Kummer I; Clinical Pharmacy Department, Faculty of Pharmacy, Marmara University, Istanbul, 34668, Turkey.
  • Sesto S; Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University, Hradec Kralove, 500 05, Czech Republic.
  • Capiau A; Department of Social Pharmacy and Pharmaceutical Legislation, Faculty of Pharmacy, University of Belgrade, 11221, Belgrade, Serbia.
  • Hadziabdic MO; Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, 9000, Ghent, Belgium.
  • Tachkov K; Department of Pharmacy, Ghent University Hospital, 9000, Ghent, Belgium.
  • Bobrova V; Centre for Applied Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, 10000, Zagreb, Croatia.
Sci Rep ; 12(1): 16774, 2022 10 06.
Article em En | MEDLINE | ID: mdl-36202826
We aimed to systematically review the prevalence of potentially inappropriate prescribing (PIP) in older adults in Central and Eastern Europe (CEE) in all care settings. We searched Embase and MEDLINE (up to June 2019) and checked the reference lists of the included studies and relevant reviews. Eligible studies used validated explicit or implicit tools to assess the PIP prevalence in older adults in CEE. All study designs were considered, except case‒control studies and case series. We assessed the risk of bias using the Joanna Briggs Institute Prevalence Critical Appraisal Tool and the certainty of evidence using the GRADE approach. Meta-analysis was inappropriate due to heterogeneity in the outcome measurements. Therefore, we used the synthesis without meta-analysis approach-summarizing effect estimates method. This review included twenty-seven studies with 139,693 participants. Most studies were cross-sectional and conducted in high-income countries. The data synthesis across 26 studies revealed the PIP prevalence: the median was 34.6%, the interquartile range was 25.9-63.2%, and the range was 6.5-95.8%. The certainty of this evidence was very low due to the risk of bias, imprecision, and inconsistency. These findings show that PIP is a prevalent issue in the CEE region. Further well-designed studies conducted across countries are needed to strengthen the existing evidence and increase the generalizability of findings.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prescrição Inadequada Tipo de estudo: Observational_studies / Prevalence_studies / Systematic_reviews Limite: Aged / Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prescrição Inadequada Tipo de estudo: Observational_studies / Prevalence_studies / Systematic_reviews Limite: Aged / Humans País/Região como assunto: Europa Idioma: En Ano de publicação: 2022 Tipo de documento: Article