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Post-translational modifications and age-related hearing loss.
Bazard, Parveen; Pineros, Jennifer; Acosta, Alejandro A; Thivierge, Mark; Paganella, Lauren R; Zucker, Samuel; Mannering, Freyda L; Modukuri, Shrikar; Zhu, Xiaoxia; Frisina, Robert D; Ding, Bo.
Afiliação
  • Bazard P; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Pineros J; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Acosta AA; School of Medicine, University of Puerto Rico, San Juan 00925, Puerto Rico; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Thivierge M; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Paganella LR; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Zucker S; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Mannering FL; Morsani College of Medicine, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Modukuri S; Biomedical Sciences - Dept. of Chemistry, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Zhu X; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
  • Frisina RD; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Department Communication Sciences and Disorders, College of Behavioral & Communication Sciences, Tampa, FL 33620, USA; Morsani College of Medicine, University of South Florida, Tampa, FL
  • Ding B; Department of Medical Engineering, College of Engineering, University of South Florida, Tampa, FL 33620, USA; Global Center for Hearing and Speech Research, University of South Florida, Tampa, FL 33612, USA.
Hear Res ; 426: 108625, 2022 12.
Article em En | MEDLINE | ID: mdl-36215796
Post-translational modifications (PTMs) affect nearly all systems of the human body due to their role in protein synthesis and functionality. These reversible and irreversible modifications control the structure, localization, activity, and properties of proteins. For this reason, PTMs are essential in regulating cellular processes and maintaining homeostasis. Diseases such as Alzheimer's, cardiovascular disease, diabetes, cancer, and many others have been linked to dysfunctions of PTMs. Recent research has also shown that irregularities in PTMs can be linked to hearing loss, including age-related hearing loss (ARHL) - the number one communication disorder and one of the top neurodegenerative diseases in our aging population. So far, there has been no FDA approved treatment for ARHL; however, translational studies investigating PTMs involvement in ARHL show promising results. In this review, we summarize key findings for PTMs within the auditory system, the involvement of PTMs with aging and ARHL, and lastly discuss potential treatment options focusing on utilizing PTMs as biomarkers and therapeutic pathway components.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Presbiacusia / Surdez Limite: Aged / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Presbiacusia / Surdez Limite: Aged / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article