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Human papillomavirus integration perspective in small cell cervical carcinoma.
Wang, Xiaoli; Jia, Wenlong; Wang, Mengyao; Liu, Jihong; Zhou, Xianrong; Liang, Zhiqing; Zhang, Qinghua; Long, Sixiang; Quzhen, Suolang; Li, Xiangchun; Tian, Qiang; Li, Xiong; Sun, Haiying; Zhao, Caili; Meng, Silu; Ning, Ruoqi; Xi, Ling; Wang, Lin; Zhou, Shasha; Zhang, Jianwei; Wu, Li; Chen, Yile; Liu, Aijun; Ma, Yaqi; Zhao, Xia; Cheng, Xiaodong; Zhang, Qing; Han, Xiaobing; Pan, Huaxiong; Zhang, Yuan; Cao, Lili; Wang, Yiqin; Ling, Shaoping; Cao, Lihua; Xing, Hui; Xu, Chang; Sui, Long; Wang, Shixuan; Zhou, Jianfeng; Kong, Beihua; Xie, Xing; Chen, Gang; Li, Shuaicheng; Ma, Ding; Li, Shuang.
Afiliação
  • Wang X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Jia W; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Wang M; City University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China.
  • Liu J; City University of Hong Kong Shenzhen Research Institute, Shenzhen, P. R. China.
  • Zhou X; Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China.
  • Liang Z; Obstetrics and Gynecology Hospital of Fudan University, Shanghai, P. R. China.
  • Zhang Q; Department of Gynecologic Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
  • Long S; Department of Gynecology & Obstetrics, The Central Hospital of Wuhan, Wuhan, P. R. China.
  • Quzhen S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Li X; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Tian Q; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Li X; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Sun H; Tianjin Cancer Institute, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P. R. China.
  • Zhao C; National Infrastructures of Translational Medicine (Shanghai), Shanghai JiaoTong University School of Medicine, Shanghai, P. R. China.
  • Meng S; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Ning R; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Xi L; Department of Gynecology & Obstetrics, The Central Hospital of Wuhan, Wuhan, P. R. China.
  • Wang L; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Zhou S; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Zhang J; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Wu L; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Chen Y; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Liu A; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Ma Y; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Zhao X; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Cheng X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Zhang Q; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Han X; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Pan H; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Zhang Y; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Cao L; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Wang Y; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Ling S; Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, 430030, Wuhan, Hubei, P. R. China.
  • Cao L; Department of Gynecologic Oncology, Hunan ProvinceTumor Hospital, Changsha, P. R. China.
  • Xing H; Department of Gynecologic Oncology, Hunan ProvinceTumor Hospital, Changsha, P. R. China.
  • Xu C; Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing, P. R. China.
  • Sui L; Department of Pathology, Chinese People's Liberation Army General Hospital, Beijing, P. R. China.
  • Wang S; Department of Gynecologic Oncology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, P. R. China.
  • Zhou J; Women's Reproductive Health Laboratory of Zhejiang Province, Zhejiang, P. R. China.
  • Kong B; Department of Gynecology & Obstetrics, Qilu Hospital, Shandong University, Jinan, Shandong, P. R. China.
  • Xie X; Department of Obstetrics and Gynecology, the First Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, P. R. China.
  • Chen G; UnionHospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Li S; UnionHospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China.
  • Ma D; Department of Gynecology & Obstetrics, The Central Hospital of Wuhan, Wuhan, P. R. China.
  • Li S; Department of Gynecologic Oncology, Southwest Hospital, Third Military Medical University, Chongqing, P. R. China.
Nat Commun ; 13(1): 5968, 2022 10 10.
Article em En | MEDLINE | ID: mdl-36216793
ABSTRACT
Small cell cervical carcinoma (SCCC) is a rare but aggressive malignancy. Here, we report human papillomavirus features and genomic landscape in SCCC via high-throughput HPV captured sequencing, whole-genome sequencing, whole-transcriptome sequencing, and OncoScan microarrays. HPV18 infections and integrations are commonly detected. Besides MYC family genes (37.9%), we identify SOX (8.4%), NR4A (6.3%), ANKRD (7.4%), and CEA (3.2%) family genes as HPV-integrated hotspots. We construct the genomic local haplotype around HPV-integrated sites, and find tandem duplications and amplified HPV long control regions (LCR). We propose three prominent HPV integration patterns duplicating oncogenes (MYCN, MYC, and NR4A2), forming fusions (FGFR3-TACC3 and ANKRD12-NDUFV2), and activating genes (MYC) via the cis-regulations of viral LCRs. Moreover, focal CNA amplification peaks harbor canonical cancer genes including the HPV-integrated hotspots within MYC family, SOX2, and others. Our findings may provide potential molecular criteria for the accurate diagnosis and efficacious therapies for this lethal disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Carcinoma de Células Pequenas / Infecções por Papillomavirus / Alphapapillomavirus Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo do Útero / Carcinoma de Células Pequenas / Infecções por Papillomavirus / Alphapapillomavirus Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article