Direct C(sp3)-H Polyfluoroarylation: Access to Polyfluoroaryl Amino Acids via Rh-Catalyzed Selective C-F Bond Cleavage.
J Org Chem
; 87(21): 14476-14486, 2022 11 04.
Article
em En
| MEDLINE
| ID: mdl-36226632
ABSTRACT
A catalytic selective C-F bond alkylation method for polyfluoroarene with glycinates and derivatives in the presence of a DavePhos-ligated Rh catalyst was developed. This method avoids the preactivation of alkylating reagents and provides an efficient and straightforward route to synthesize a series of polyfluoroaryl amino acids via C(sp3)-H functionalization. This reaction proceeds under mild conditions and exhibits high reactivity and excellent chemoselectivities. Meanwhile, the synthetic potential of this method was demonstrated by gram-scale synthesis, and further transformations proved the application value of the products as well.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ródio
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article