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Synthesis, computational investigation and biological evaluation of α,α-difluoromethyl ketones embodying pyrazole and isoxazole nuclei as COX inhibitors.
Citarella, Andrea; Ielo, Laura; Stagno, Claudio; Cristani, Mariateresa; Muscarà, Claudia; Pace, Vittorio; Micale, Nicola.
Afiliação
  • Citarella A; University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy. nmicale@unime.it.
  • Ielo L; University of Torino, Department of Chemistry, Via P. Giuria 7, 10125 Torino, Italy. vittorio.pace@unito.it.
  • Stagno C; University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy. nmicale@unime.it.
  • Cristani M; University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy. nmicale@unime.it.
  • Muscarà C; University of Messina, Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Viale Ferdinando Stagno D'Alcontres 31, I-98166 Messina, Italy. nmicale@unime.it.
  • Pace V; University of Torino, Department of Chemistry, Via P. Giuria 7, 10125 Torino, Italy. vittorio.pace@unito.it.
  • Micale N; University of Vienna, Department of Pharmaceutical Sciences, Josef-Holaubek-Platz 2-1090, Vienna, Austria. vittorio.pace@univie.ac.at.
Org Biomol Chem ; 20(42): 8293-8304, 2022 Nov 02.
Article em En | MEDLINE | ID: mdl-36227250
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isoxazóis / Cetonas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Isoxazóis / Cetonas Tipo de estudo: Guideline Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article