Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins.

Kalshetti, Rupali G; Rajput, Raveena; Motiwala, Zenia; Srinivasa Reddy, D; Kulkarni, Kiran A; Ramana, Chepuri V

Kalshetti, Rupali G; Rajput, Raveena; Motiwala, Zenia; Srinivasa Reddy, D; Kulkarni, Kiran A; Ramana, Chepuri V.

Afiliação

Kalshetti RG; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Rajput R; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
Motiwala Z; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Srinivasa Reddy D; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.
Kulkarni KA; Biochemical Science Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: ka.kulkarni@ncl.res.in.
Ramana CV; Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address: vr.chepuri@ncl.res.in.

Bioorg Med Chem Lett ; 77: 129022, 2022 12 01.

Article em En | MEDLINE | ID: mdl-36241050

Assuntos

Alcenos; Benzaldeídos; Alcenos/química; Catálise; Pirazóis

Palavras-chave

CDC Coupling; GBT-440 (Voxelotor); Rh(III) catalysis; Sickle Cell Anemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzaldeídos / Alcenos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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