Prostaglandin production selectively in brain endothelial cells is both necessary and sufficient for eliciting fever.
Proc Natl Acad Sci U S A
; 119(43): e2122562119, 2022 10 25.
Article
em En
| MEDLINE
| ID: mdl-36252026
ABSTRACT
Fever is known to be elicited by prostaglandin E2 acting on the brain, but its origin has remained disputed. We show in mice that selective deletion of prostaglandin synthesis in brain endothelial cells, but not in neural cells or myeloid cells, abolished fever induced by intravenous administration of lipopolysaccharide and that selective rescue of prostaglandin synthesis in brain endothelial cells reinstated fever. These data demonstrate that prostaglandin production in brain endothelial cells is both necessary and sufficient for eliciting fever.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dinoprostona
/
Células Endoteliais
/
Febre
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article