Spontaneous regression of an human papillomavirus-positive oropharyngeal squamous cell carcinoma.
Head Neck
; 45(1): E1-E4, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36256583
ABSTRACT
BACKGROUND:
Spontaneous regression (SR) of cancer is an exceedingly rare phenomenon. While SR is well-documented for some cancers, very few reports exist in oropharyngeal squamous cell carcinomas (OPSCCs) and none in human papillomavirus (HPV)-positive OPSCCs.METHODS:
A 67-year old man presented with a left-sided neck mass. Neck CT, PET, and biopsies showed a SCC in a left-sided lymph node without a primary lesion. Immunohistochemistry confirmed HPV16. Six weeks after biopsy, the patient underwent left selective tonsillectomy and neck dissection.RESULTS:
Surgery revealed a left tonsillar SCC and no lymph nodes with tumor. Histology revealed homogenous fibrosis and intermixed immune cells indicative of tumor regression analogous to reports of immune-related pathologic responses. AE1/AE3 immunostain was also negative for tumor. All lymph nodes remained negative at 1 year follow-up.CONCLUSION:
We described a spontaneously regressed lymph node in a tonsillar HPV-positive SCC. The unique immune environment of HPV-positive OPSCCs, and unknown environmental or host factors, may have played a role in our patient's SR which requires future studies to elucidate.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
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Neoplasias Orofaríngeas
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Neoplasias Tonsilares
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Infecções por Papillomavirus
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Neoplasias de Cabeça e Pescoço
Limite:
Aged
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Humans
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Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article