A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase.

Shankar, Srihari; Ramachandran, Sarath; Tulsian, Nikhil; Radhakrishnan, Sridhar; Jobichen, Chacko; Sivaraman, J

Shankar, Srihari; Ramachandran, Sarath; Tulsian, Nikhil; Radhakrishnan, Sridhar; Jobichen, Chacko; Sivaraman, J.

Afiliação

Shankar S; Department of Biological Sciences, National University of Singapore, Singapore.
Ramachandran S; Department of Biological Sciences, National University of Singapore, Singapore.
Tulsian N; Department of Biological Sciences, National University of Singapore, Singapore.
Radhakrishnan S; Department of Biochemistry, Yong Loo Ling School of Medicine, National University of Singapore, Singapore.
Jobichen C; Cancer Science Institute, National University of Singapore, Singapore.
Sivaraman J; Department of Biological Sciences, National University of Singapore, Singapore.

FEBS J ; 290(9): 2437-2448, 2023 05.

Article em En | MEDLINE | ID: mdl-36259273

Assuntos

Antineoplásicos; Glutaminase; Humanos; Sítio Alostérico; Glutaminase/genética; Glutaminase/metabolismo; Rim/metabolismo; Antineoplásicos/farmacologia; Antineoplásicos/química; Mutação

Palavras-chave

allosteric site; crystal structure; glutaminase; inhibition mechanism; small molecule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glutaminase / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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