Striatal Dopamine Transporter Availability is Associated with Sleep Disturbance among Patients with Bipolar I Disorder: A Single-photon Emission Computed Tomography Study Using [99mTc] TRODAT-1.
Clin Psychopharmacol Neurosci
; 20(4): 768-772, 2022 Nov 30.
Article
em En
| MEDLINE
| ID: mdl-36263651
ABSTRACT
Objective:
Bipolar disorder (BD) is characterized by the poor sleep quality. Whether the striatal dopamine transporter (DAT) availability is related to sleep quality among patients with BD is unclear.Methods:
Fifty-three euthymic patients with BD (24 BD-I and 29 BD-II) and sixty-eight healthy controls were enrolled. The Chinese Version of the Pittsburgh Sleep Quality Index (PSQI) was used, and the availability of DAT was assessed by single-photon emission computed tomography (SPECT) using [99mTc] TRODAT-1.Results:
The sleep disturbance component of the PSQI was significantly associated with the level of DAT availability among patients with BD.Conclusion:
The striatal dopaminergic activity that contributes to resilience to adversity was associated with sleep pattern among patients with BD.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article