ε-Benzylation via Cooperative Photoredox and N-Heterocyclic Carbene Catalysis.
J Org Chem
; 87(21): 14970-14974, 2022 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-36264188
ABSTRACT
The ε-benzylation of γ-alkenyl-γ-oxidized enals via dual photoredox and N-heterocyclic carbene catalysis has been developed, affording the corresponding ε-benzyl-α,ß-γ,δ-bisunsaturated esters in moderate to good yields with exclusive regioselectivities. The reaction is proposed via the generation of benzyl radical under photocatalysis, followed by its addition to an NHC-bound trienolate intermediate.
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Coleções:
01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article