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Systematic review and meta-analysis of occult contralateral nodal metastases in patients with oropharyngeal squamous carcinoma undergoing elective neck dissection.
Malik, Akshat; Hardman, John C; Devabalan, Yadsan; Nutting, Christopher; Bhide, Shreerang; Harrington, Kevin; Schilling, Clare; Paleri, Vinidh.
Afiliação
  • Malik A; Department of Surgical Oncology, Max Superspeciality Hospital, Saket, New Delhi, India. Electronic address: akshatmalik@gmail.com.
  • Hardman JC; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: johncharles.hardman@nhs.net.
  • Devabalan Y; Department of Otolaryngology-Head Neck Surgery, Imperial College NHS Trust, London, United Kingdom. Electronic address: yadsan.devabalan@nhs.net.
  • Nutting C; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Chris.Nutting@rmh.nhs.uk.
  • Bhide S; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: Shreerang.Bhide@rmh.nhs.uk.
  • Harrington K; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: kevin.harrington@icr.ac.uk.
  • Schilling C; Head and Neck Academic Centre, Department of Head and Neck Surgery, University College London Hospital, London, UK. Electronic address: clare.schilling@nhs.net.
  • Paleri V; Head and Neck Unit, The Royal Marsden NHS Foundation Trust, London, United Kingdom. Electronic address: vinidh.paleri@rmh.nhs.uk.
Eur J Surg Oncol ; 49(2): 316-322, 2023 02.
Article em En | MEDLINE | ID: mdl-36270881
A systematic review and meta-analysis was conducted to evaluate the occult contralateral nodal metastases (OCM) in patients undergoing bilateral neck dissection for surgically treated oropharyngeal squamous cell carcinoma (OPSCC). Following PRISMA guidelines, MEDLINE, Embase and Cochrane Controlled Register of Trials databases were searched for observational and experimental studies until March 2021. Search yielded 175 articles, of which 13 were included. Overall, OCM were seen in 9.8% of patients (95% CI: [5.7, 16.4], 839 patients, 12 studies, I2 65%). For ipsilateral cN0 necks, the OCM rate was 1.7% (95% CI: [0.1, 22.4], 150 patients, 8 studies, I2 0%) and for cN + necks the OCM rate was 9.8% (95% CI: [4.4, 20.3], 429 patients, 8 studies, I2 72%). Occult contralateral nodal metastases are uncommon in OPSCC patients with clinico-radiologically negative ipsilateral necks. Occult rates are higher in the contralateral neck when the ipsilateral neck is clinico-radiologically node positive.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Tipo de estudo: Guideline / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Tipo de estudo: Guideline / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article