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Two new compounds from Verbena bonariensis.
Li, Rui; Chen, Yuan-Si; Bi, De-Wen; Wei, Qiong; Zhou, Ya-Ling; Qiu, Xiong; Zhang, Rui-Han; Zhang, Xing-Jie; Xiao, Wei-Lie; Li, Hong-Liang; Li, Xiao-Li.
Afiliação
  • Li R; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Chen YS; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Bi DW; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Wei Q; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Zhou YL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Qiu X; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Zhang RH; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Zhang XJ; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Xiao WL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
  • Li HL; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, China.
  • Li XL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research and Development of Natural Products; School of Pharmacy, School of Chemical Science and Technology and School of Medicine, Yunnan University, Kunming 650500, China.
J Asian Nat Prod Res ; 25(7): 658-666, 2023.
Article em En | MEDLINE | ID: mdl-36272136
ABSTRACT
Two new compounds verboncin A (1) and verboncin B (4) and 14 known compounds (2-3 and 5-16) were isolated from Verbena bonariensis, and these 14 compounds were first obtained from this plant. Their chemical structures were established by one and two-dimensional NMR and HRESIMS analysis and the results were compared with literature values. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD). The cytotoxicity of some of the compounds against MCF-7, HCT-116, MDA-MB-231, and SW620 human cancer cell lines were evaluated, in which compound 4 showed negligible cytotoxic activity with an IC50 value of 68.08 ± 0.35 µM against the MCF-7 cell line.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Verbena Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Verbena Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article