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CAR cell design strategies in solid tumors.
Wang, Lu; Chen, Xinyi; Zhang, Lu; Niu, Boning; Li, Long; Sun, Yinan; Yuan, Xianglin.
Afiliação
  • Wang L; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China.
  • Chen X; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China.
  • Zhang L; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China.
  • Niu B; Tongji School of Pharmacy, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, Hubei, China.
  • Li L; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China.
  • Sun Y; Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China. Electronic address: sunyinan@hust.edu.cn.
  • Yuan X; Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jie Fang Road 1095, Wuhan, Hubei, China. Electronic address: yuanxianglin@hust.edu.cn.
Int Immunopharmacol ; 113(Pt A): 109345, 2022 Dec.
Article em En | MEDLINE | ID: mdl-36272358
In addition to chimeric antigen receptor (CAR)-αß T-cell therapy, CAR-NK, CAR-NKT, CAR-M and CAR-γδ T-cell therapy have gradually been applied to the treatment of solid tumors. Compared to hematological tumors, solid tumors have the characteristics of strong tumor heterogeneity, limited target antigen selection, and low T-cell infiltration to build immunosuppressive tumor microenvironment. These features would present great obstacles to CAR cell therapy. This paper comprehensively analyzed the application of different CAR cells to solid tumors and summarized the design principles of different CAR cells to provide the direction for the development of CAR cell therapy in solid tumors.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article