Optimization design of sialic acid derivatives enhances the performance of liposomes for modulating immunosuppressive tumor microenvironments.

Sui, Dezhi; Liang, Kaifan; Gui, Yangxu; Du, Zhouchunxiao; Xin, Dongzhe; Yu, Guojing; Zhai, Wantong; Liu, Xinrong; Song, Yanzhi; Deng, Yihui

Sui, Dezhi; Liang, Kaifan; Gui, Yangxu; Du, Zhouchunxiao; Xin, Dongzhe; Yu, Guojing; Zhai, Wantong; Liu, Xinrong; Song, Yanzhi; Deng, Yihui.

Afiliação

Sui D; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Liang K; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Gui Y; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Du Z; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Xin D; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Yu G; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Zhai W; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Liu X; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.
Song Y; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China. Electronic address: songyanzhi@syphu.edu.cn.
Deng Y; College of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, No. 103, Shenyang 110016, China.

Life Sci ; 310: 121081, 2022 Dec 01.

Article em En | MEDLINE | ID: mdl-36273630

Assuntos

Lipossomos; Neoplasias; Animais; Lipossomos/química; Microambiente Tumoral; Ácido N-Acetilneuramínico/química; Ácido N-Acetilneuramínico/farmacologia; Linfócitos T CD8-Positivos/metabolismo; Neoplasias/tratamento farmacológico; Colesterol/química; Amidas/farmacologia; Linhagem Celular Tumoral

Palavras-chave

CD8(+) T cells; Doxorubicin; Liposomes; Sialic acid-cholesterol conjugate; Sialic acid-derivatives; Tumor associated macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lipossomos / Neoplasias Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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