Spinal GABAergic disinhibition allows microglial activation mediating the development of nociplastic pain in male mice.

McDonough, Kathleen E; Hammond, Regan; Wang, Jigong; Tierney, Jessica; Hankerd, Kali; Chung, Jin Mo; La, Jun-Ho

McDonough, Kathleen E; Hammond, Regan; Wang, Jigong; Tierney, Jessica; Hankerd, Kali; Chung, Jin Mo; La, Jun-Ho.

Afiliação

McDonough KE; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
Hammond R; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
Wang J; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
Tierney J; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
Hankerd K; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
Chung JM; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States.
La JH; Department of Neurobiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, United States. Electronic address: jula@utmb.edu.

Brain Behav Immun ; 107: 215-224, 2023 01.

Article em En | MEDLINE | ID: mdl-36273650

Assuntos

Hiperalgesia; Dor; Animais; Masculino; Camundongos; Glicoproteínas de Membrana; Microglia; Agonistas GABAérgicos

Palavras-chave

ATP; Disinhibition; GABA; Microglia; Nociplastic pain; P2X4; Proinflammatory cytokines

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Hiperalgesia Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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