Discovery of 5-(3,4-dihydroxybenzylidene)-1,3-dimethylpyrimidine- 2,4,6(1H,3H,5H)-trione as a novel and effective cardioprotective agent via dual anti-inflammatory and anti-oxidative activities.

Shi, Yang-Yang; Wei, Bo; Zhou, Jing; Yin, Zhi-Li; Zhao, Fei; Peng, Ya-Jie; Yu, Qing-Wen; Wang, Xin-Lu; Chen, Ya-Jing

Shi, Yang-Yang; Wei, Bo; Zhou, Jing; Yin, Zhi-Li; Zhao, Fei; Peng, Ya-Jie; Yu, Qing-Wen; Wang, Xin-Lu; Chen, Ya-Jing.

Afiliação

Shi YY; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Wei B; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Zhou J; College of Medicine, Henan Vocational University of Science and Technology, 6 Wenchang Avenue, Zhoukou, 466000, Henan, China.
Yin ZL; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Zhao F; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Peng YJ; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Yu QW; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Wang XL; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China.
Chen YJ; School of Pharmaceutical Sciences, Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Zhengzhou University, 100 Science Avenue, Zhengzhou, 450001, Henan, China. Electronic address: chenyj@zzu.edu.cn.

Eur J Med Chem ; 244: 114848, 2022 Dec 15.

Article em En | MEDLINE | ID: mdl-36274277

Assuntos

Anti-Inflamatórios; Cardiotônicos; Cinamatos; Isquemia Miocárdica; Traumatismo por Reperfusão Miocárdica; Animais; Ratos; Anti-Inflamatórios/química; Anti-Inflamatórios/farmacologia; Anti-Inflamatórios/uso terapêutico; Cardiotônicos/química; Cardiotônicos/farmacologia; Cardiotônicos/uso terapêutico; Simulação de Acoplamento Molecular; Isquemia Miocárdica/tratamento farmacológico; Traumatismo por Reperfusão Miocárdica/tratamento farmacológico; Miócitos Cardíacos/efeitos dos fármacos; Fator 2 Relacionado a NF-E2/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Ratos Sprague-Dawley; Cinamatos/química; Cinamatos/farmacologia; Cinamatos/uso terapêutico

Palavras-chave

Cinnamoyl derivatives; Daul effects; Inflammation; Myocardial ischemia/reperfusion injury; Oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiotônicos / Traumatismo por Reperfusão Miocárdica / Cinamatos / Isquemia Miocárdica / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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