"Rogue" neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury - <i>studies in human, macaque and rat LPS-inflammation models</i>.

Carstensen, Saskia; Müller, Meike; Tan, Glaiza L A; Pasion, Khristine Amber; Hohlfeld, Jens M; Herrera, Victoria L M; Ruiz-Opazo, Nelson

"Rogue" neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury - studies in human, macaque and rat LPS-inflammation models.

Carstensen, Saskia; Müller, Meike; Tan, Glaiza L A; Pasion, Khristine Amber; Hohlfeld, Jens M; Herrera, Victoria L M; Ruiz-Opazo, Nelson.

Afiliação

Carstensen S; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Department of Biomarker Analysis and Development, Hannover, Germany.
Müller M; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Department of Biomarker Analysis and Development, Hannover, Germany.
Tan GLA; Whitaker Cardiovascular Institute and Department of Medicine, Boston University School of Medicine, Boston MA, United States.
Pasion KA; Whitaker Cardiovascular Institute and Department of Medicine, Boston University School of Medicine, Boston MA, United States.
Hohlfeld JM; Fraunhofer Institute for Toxicology and Experimental Medicine ITEM, Department of Biomarker Analysis and Development, Hannover, Germany.
Herrera VLM; Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.
Ruiz-Opazo N; Member of the German Center for Lung Research (DZL), Hannover, Germany.

Front Immunol ; 13: 1008390, 2022.

Article em En | MEDLINE | ID: mdl-36275710

Assuntos

Lesão Pulmonar Aguda; Encefalopatias; Síndrome do Desconforto Respiratório; Humanos; Ratos; Animais; Lipopolissacarídeos/efeitos adversos; Neutrófilos; Macaca mulatta; Lesão Pulmonar Aguda/metabolismo; Inflamação/metabolismo; Síndrome do Desconforto Respiratório/tratamento farmacológico; Hipóxia/metabolismo; Encefalopatias/metabolismo

Palavras-chave

DEspR; LPS-acute inflammation tissue injury models; LPS-brain encephalopathy; acute lung injury; neutrophil subset; segmental LPS challenge

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Encefalopatias / Lesão Pulmonar Aguda Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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