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Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation.
Bone, Ruth; Fennell, Brian J; Tam, Amy; Sheldon, Richard; Nocka, Karl; Varghese, Sreeja; Chang, Chew Shun; Hawerkamp, Heike C; Yeow, Aoife; Saunders, Sean P; Hams, Emily; Walsh, Patrick T; Cunningham, Orla; Fallon, Padraic G.
Afiliação
  • Bone R; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland.
  • Fennell BJ; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland.
  • Tam A; BioMedicine Design, Pfizer, Cambridge, MA, 02139, USA.
  • Sheldon R; Inflammation & Immunology, Pfizer, Cambridge, MA, 02139, USA.
  • Nocka K; Inflammation & Immunology, Pfizer, Cambridge, MA, 02139, USA.
  • Varghese S; BioMedicine Design, Pfizer, Grange Castle Business Park, Clondalkin, Dublin 22, Ireland.
  • Chang CS; BioMedicine Design, Pfizer, Cambridge, MA, 02139, USA.
  • Hawerkamp HC; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
  • Yeow A; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
  • Saunders SP; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
  • Hams E; Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, Dublin 2, Ireland.
  • Walsh PT; National Children's Research Centre, Our Lady's Children's Hospital, Dublin 12, Ireland.
  • Cunningham O; Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
  • Fallon PG; UltraHuman Eight Limited, C/o Kreston Reeves Llp, Kent, CT139FF, UK.
Antib Ther ; 5(4): 258-267, 2022 Oct.
Article em En | MEDLINE | ID: mdl-36299415
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article