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A novel pulsatile blood pump design for cardiothoracic surgery: Proof-of-concept in a mock circulation.
Weber, Elena; Chong, Albert; Liebold, Andreas; Hoenicka, Markus.
Afiliação
  • Weber E; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
  • Chong A; Triphasic Cardiac Pump Pty Ltd, Nedlands, Western Australia, Australia.
  • Liebold A; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
  • Hoenicka M; Department of Cardiothoracic and Vascular Surgery, Ulm University Medical Center, Ulm, Germany.
Artif Organs ; 47(3): 512-525, 2023 Mar.
Article em En | MEDLINE | ID: mdl-36300590
BACKGROUND: Pulsatile perfusion during extracorporeal circulation is a promising concept to improve perfusion of critical organs. Clinical benefits are limited by the amount of pulsatile energy provided by standard pumps. The present study investigated the properties of a novel positive displacement blood pump in a mock circulation. METHODS: The pump was attached to an aortic model with a human-like geometry and compliance as a pseudo patient. Hemodynamic data were recorded while the pump settings were adjusted systematically. RESULTS: Using a regular oxygenator, maximum flow was 2.6 L/min at a pressure of 27 mm Hg and a frequency (F) of 90 bpm. Pulse pressure (PP; 28.9 mm Hg) and surplus hemodynamic energy (SHE; 26.1% of mean arterial pressure) were highest at F = 40 bpm. Flow and pressure profiles appeared sinusoid. Using a low-resistance membrane ventilator to assess the impact of back pressure, maximum flow was 4.0 L/min at a pressure of 58.6 mm Hg and F = 40 bpm. At F = 40 bpm, PP was 58.7 mm Hg with an SHE of 33.4%. SHE decreased with increasing flow, heart rate, and systolic percentage but surpassed 10% with reasonable settings. CONCLUSIONS: The present prototype achieved sufficient flow and pressure ranges only in the presence of a low-resistance membrane ventilator. It delivered supraphysiologic levels of pulse pressure and SHE. Further modifications are planned to establish this concept for adult pulsatile perfusion.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Circulação Extracorpórea / Hemodinâmica Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Circulação Extracorpórea / Hemodinâmica Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article