Dual tumor- and subcellular-targeted photodynamic therapy using glucose-functionalized MoS<sub>2</sub> nanoflakes for multidrug-resistant tumor ablation.

Xu, Shaohui; Zhang, Pan; Heing-Becker, Isabelle; Zhang, Junmei; Tang, Peng; Bej, Raju; Bhatia, Sumati; Zhong, Yinan; Haag, Rainer

Dual tumor- and subcellular-targeted photodynamic therapy using glucose-functionalized MoS₂ nanoflakes for multidrug-resistant tumor ablation.

Xu, Shaohui; Zhang, Pan; Heing-Becker, Isabelle; Zhang, Junmei; Tang, Peng; Bej, Raju; Bhatia, Sumati; Zhong, Yinan; Haag, Rainer.

Afiliação

Xu S; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Zhang P; School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, 211198, Nanjing, China.
Heing-Becker I; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Zhang J; School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, 211198, Nanjing, China.
Tang P; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Bej R; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Bhatia S; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Zhong Y; School of Engineering, China Pharmaceutical University, 639 Longmian Avenue, 211198, Nanjing, China. Electronic address: ynzhong@cpu.edu.cn.
Haag R; Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany. Electronic address: haag@chemie.fu-berlin.de.

Biomaterials ; 290: 121844, 2022 11.

Article em En | MEDLINE | ID: mdl-36302305

Assuntos

Nanopartículas; Fotoquimioterapia; Camundongos; Animais; Espécies Reativas de Oxigênio/metabolismo; Molibdênio; Glucose; Linhagem Celular Tumoral; Adenosina; Citosina; Fármacos Fotossensibilizantes/uso terapêutico; Fármacos Fotossensibilizantes/farmacologia; Nanopartículas/química

Palavras-chave

Endoplasmic reticulum stress; Mitochondrial dysfunction; Molybdenum disulfide; Photodynamic therapy; Reversal of tumor multidrug-resistance; precise subcellular organelle targeting

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fotoquimioterapia / Nanopartículas Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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