NMR spectroscopy as a characterization tool enabling biologics formulation development.

Ma, Junhe; Pathirana, Charles; Liu, David Q; Miller, Scott A

Ma, Junhe; Pathirana, Charles; Liu, David Q; Miller, Scott A.

Afiliação

Ma J; Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, United States. Electronic address: junhe.ma@bms.com.
Pathirana C; Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, United States.
Liu DQ; Vertex Pharmaceuticals, 50 Northern Avernue, Boston, MA 02210, United States.
Miller SA; Chemical Process Development, Bristol Myers Squibb Company, 1 Squibb Drive, New Brunswick, NJ 08903, United States.

J Pharm Biomed Anal ; 223: 115110, 2023 Jan 20.

Article em En | MEDLINE | ID: mdl-36308923

Assuntos

Produtos Biológicos; Excipientes; Excipientes/química; Espectroscopia de Ressonância Magnética/métodos; Estabilidade Proteica; Anticorpos Monoclonais/química

Palavras-chave

Biologics formulation; Higher order structure; NMR fingerprinting; Solution NMR; Therapeutic proteins; XL-ALSOFAST-HMQC

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Excipientes Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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