Atorvastatin-induced tolerogenic dendritic cells improve cardiac remodeling by suppressing TLR-4/NF-&#954;B activation after myocardial infarction.

Wang, Qian; Chen, Zhaoyang; Guo, Junjie; Peng, Xiaoping; Zheng, Zeqi; Chen, Hang; Liu, Haibo; Ma, Yuanji; Zhu, Jianbing

Atorvastatin-induced tolerogenic dendritic cells improve cardiac remodeling by suppressing TLR-4/NF-κB activation after myocardial infarction.

Wang, Qian; Chen, Zhaoyang; Guo, Junjie; Peng, Xiaoping; Zheng, Zeqi; Chen, Hang; Liu, Haibo; Ma, Yuanji; Zhu, Jianbing.

Afiliação

Wang Q; Department of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, People's Republic of China.
Chen Z; Heart Center of Fujian Province, Union Hospital, Fujian Medical University, 29 Xin-Quan Road, Fuzhou, 350001, People's Republic of China.
Guo J; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, People's Republic of China.
Peng X; Qingdao Municipal Key Laboratory of Hypertension, Qingdao, Shandong, People's Republic of China.
Zheng Z; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, People's Republic of China.
Chen H; Jiangxi Hypertension Research Institute, Nanchang, People's Republic of China.
Liu H; Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi Province, People's Republic of China.
Ma Y; Jiangxi Hypertension Research Institute, Nanchang, People's Republic of China.
Zhu J; Heart Center of Fujian Province, Union Hospital, Fujian Medical University, 29 Xin-Quan Road, Fuzhou, 350001, People's Republic of China.

Inflamm Res ; 72(1): 13-25, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36315279

Assuntos

Infarto do Miocárdio; NF-kappa B; Camundongos; Animais; Atorvastatina/farmacologia; Atorvastatina/uso terapêutico; Atorvastatina/metabolismo; NF-kappa B/metabolismo; Remodelação Ventricular/fisiologia; Receptor 4 Toll-Like/metabolismo; Volume Sistólico; Função Ventricular Esquerda; Infarto do Miocárdio/tratamento farmacológico; Miócitos Cardíacos; Apoptose; Citocinas/metabolismo; Fibrose; Células Dendríticas; Modelos Animais de Doenças; Miocárdio/patologia

Palavras-chave

Atorvastatin; Myocardial fibrosis; Myocardial infarction; TLR-4; Tolerogenic dendritic cell

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Infarto do Miocárdio Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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