Celastrol acts as a new histone deacetylase inhibitor to inhibit colorectal cancer cell growth via regulating macrophage polarity.

Wang, Shuren; Hu, Guanghui; Chen, Lechuang; Ma, Kai; Hu, Chenfei; Zhu, Hongxia; Xu, Ningzhi; Zhou, Changchun; Liu, Mei

Wang, Shuren; Hu, Guanghui; Chen, Lechuang; Ma, Kai; Hu, Chenfei; Zhu, Hongxia; Xu, Ningzhi; Zhou, Changchun; Liu, Mei.

Afiliação

Wang S; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hu G; School of Medicine and Institute for Immunology, Tsinghua University, Beijing, China.
Chen L; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Ma K; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hu C; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhu H; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Xu N; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Zhou C; Laboratory of Cell and Molecular Biology & State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Liu M; Biobank, Cancer Research Center, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.

Cell Biol Int ; 47(2): 492-501, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36317450

Assuntos

Neoplasias Colorretais; Inibidores de Histona Desacetilases; Camundongos; Animais; Inibidores de Histona Desacetilases/farmacologia; Inibidores de Histona Desacetilases/metabolismo; Macrófagos/metabolismo; Triterpenos Pentacíclicos/metabolismo; Neoplasias Colorretais/metabolismo; Transformação Celular Neoplásica/metabolismo; Polaridade Celular; Microambiente Tumoral

Palavras-chave

MAPK signaling pathway; celastrol; colorectal cancer; epigenetic modification; macrophage polarization

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Inibidores de Histona Desacetilases Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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