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One-Step Regio- and Stereoselective Electrochemical Synthesis of Orexin Receptor Antagonist Oxidative Metabolites.
Yao, Huifang; Sherer, Edward C; Lu, Mei; Small, James; Martin, Gary E; Lam, Yu-Hong; Chen, Qinghao; Helmy, Roy; Liu, Yong; Chen, Hao.
Afiliação
  • Yao H; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Sherer EC; Analytical Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Lu M; Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, United States.
  • Small J; Analytical Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Martin GE; Analytical Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Lam YH; Computational and Structural Chemistry, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Chen Q; Process Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Helmy R; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Liu Y; Analytical Research and Development, MRL, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, United States.
  • Chen H; Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, United States.
J Org Chem ; 87(22): 15011-15021, 2022 11 18.
Article em En | MEDLINE | ID: mdl-36322780
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antagonistas dos Receptores de Orexina / Amidas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antagonistas dos Receptores de Orexina / Amidas Idioma: En Ano de publicação: 2022 Tipo de documento: Article