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Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα.
Liu, Xiao; Zhou, Qingtong; Hart, Jonathan R; Xu, Yingna; Yang, Su; Yang, Dehua; Vogt, Peter K; Wang, Ming-Wei.
Afiliação
  • Liu X; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Zhou Q; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Hart JR; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Xu Y; Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Yang S; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.
  • Yang D; The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China.
  • Vogt PK; The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang MW; Research Center for Deepsea Bioresources, Sanya 572025, China.
Proc Natl Acad Sci U S A ; 119(46): e2215621119, 2022 11 16.
Article em En | MEDLINE | ID: mdl-36343266
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article