2,4-Dihydroxycinnamic acid as spike ACE2 inhibitor and apigenin as RdRp inhibitor in Nimbamritadi Panchatiktam Kashayam against COVID-19: an in silico and in vitro approach.

Murali, Maneesha; Nair, Bhagyalakshmi; Vishnu, V R; Aneesh, T P; Nath, Lekshmi R

Murali, Maneesha; Nair, Bhagyalakshmi; Vishnu, V R; Aneesh, T P; Nath, Lekshmi R.

Afiliação

Murali M; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.
Nair B; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.
Vishnu VR; Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.
Aneesh TP; Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.
Nath LR; Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682 041, India.

Mol Divers ; 27(5): 2353-2363, 2023 Oct.

Article em En | MEDLINE | ID: mdl-36357813

Assuntos

Apigenina; COVID-19; Humanos; Apigenina/farmacologia; Enzima de Conversão de Angiotensina 2; Células HEK293; Descoberta de Drogas; Ligação Proteica

Palavras-chave

Nimbamritadi Panchatiktam Kashayam; Pseudovirus inhibition assay; Spike ACE2; Viral replication

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apigenina / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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