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Immune Modulation by Myeloid-Derived Suppressor Cells in Diabetic Kidney Disease.
Hsieh, Ching-Chuan; Chang, Cheng-Chih; Hsu, Yung-Chien; Lin, Chun-Liang.
Afiliação
  • Hsieh CC; Division of General Surgery, Chang Gung Memorial Hospital, Chiayi 261363, Taiwan.
  • Chang CC; Kidney and Diabetic Complications Research Team (KDCRT), Chang Gung Memorial Hospital, Chiayi 261363, Taiwan.
  • Hsu YC; Division of General Surgery, Chang Gung Memorial Hospital, Chiayi 261363, Taiwan.
  • Lin CL; Kidney and Diabetic Complications Research Team (KDCRT), Chang Gung Memorial Hospital, Chiayi 261363, Taiwan.
Int J Mol Sci ; 23(21)2022 Oct 31.
Article em En | MEDLINE | ID: mdl-36362050
Diabetic kidney disease (DKD) frequently leads to end-stage renal disease and other life-threatening illnesses. The dysregulation of glomerular cell types, including mesangial cells, endothelial cells, and podocytes, appears to play a vital role in the development of DKD. Myeloid-derived suppressor cells (MDSCs) exhibit immunoregulatory and anti-inflammatory properties through the depletion of L-arginine that is required by T cells, through generation of oxidative stress, interference with T-cell recruitment and viability, proliferation of regulatory T cells, and through the promotion of pro-tumorigenic functions. Under hyperglycemic conditions, mouse mesangial cells reportedly produce higher levels of fibronectin and pro-inflammatory cytokines. Moreover, the number of MDSCs is noticeably decreased, weakening inhibitory immune activities, and creating an inflammatory environment. In diabetic mice, immunotherapy with MDSCs that were induced by a combination of granulocyte-macrophage colony-stimulating factor, interleukin (IL)-1ß, and IL-6, reduced kidney to body weight ratio, fibronectin expression, and fibronectin accumulation in renal glomeruli, thus ameliorating DKD. In conclusion, MDSCs exhibit anti-inflammatory activities that help improve renal fibrosis in diabetic mice. The therapeutic targeting of the proliferative or immunomodulatory pathways of MDSCs may represent an alternative immunotherapeutic strategy for DKD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Nefropatias Diabéticas / Células Supressoras Mieloides Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Nefropatias Diabéticas / Células Supressoras Mieloides Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article