Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration-QTc analysis.

Engwall, Michael J; Baublits, Joel; Chandra, Fiona A; Jones, Zack W; Wahlstrom, Jan; Chui, Ray W; Vargas, Hugo M

Engwall, Michael J; Baublits, Joel; Chandra, Fiona A; Jones, Zack W; Wahlstrom, Jan; Chui, Ray W; Vargas, Hugo M.

Afiliação

Engwall MJ; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California, USA.
Baublits J; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California, USA.
Chandra FA; Amgen Clinical Pharmacology Modeling & Simulation, Thousand Oaks, California, USA.
Jones ZW; Amgen Clinical Pharmacology Modeling & Simulation, Thousand Oaks, California, USA.
Wahlstrom J; Pharmacokinetics, Amgen Research, Thousand Oaks, California, USA.
Chui RW; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California, USA.
Vargas HM; Translational Safety & Bioanalytical Sciences, Amgen Research, Thousand Oaks, California, USA.

Clin Transl Sci ; 16(3): 436-446, 2023 03.

Article em En | MEDLINE | ID: mdl-36369797

Assuntos

Fluoroquinolonas; Síndrome do QT Longo; Humanos; Cães; Animais; Macaca fascicularis; Síndrome do QT Longo/induzido quimicamente; Moxifloxacina; Telemetria

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do QT Longo / Fluoroquinolonas Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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