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Discovery of novel hydroxyamidine based indoleamine 2,3-dioxygenase 1 (IDO1) and thioredoxin reductase 1 (TrxR1) dual inhibitors.
Zhou, Ji; Yu, Li-Zhen; Fan, Ya-Li; Guo, Ci-Hao; Lv, Xiao-Mei; Zhou, Zhi-Yin; Huang, Hui-Dan; Miao, Dong-Dong; Zhang, Sheng-Peng; Li, Xin-Yu; Zhao, Ping-Ping; Liu, Xiao-Ping; Hu, Wei-Hua; Zhang, Chao.
Afiliação
  • Zhou J; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Yu LZ; School of Pharmacy, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Fan YL; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Guo CH; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Lv XM; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Zhou ZY; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Huang HD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Miao DD; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Zhang SP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China.
  • Li XY; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
  • Zhao PP; Department of Clinical Pharmacy, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, 210009, PR China.
  • Liu XP; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: liuxiaoping@wnmc.edu.cn.
  • Hu WH; Center for Reproductive Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: weihuahu@126.com.
  • Zhang C; Center of Drug Screening and Evaluation, Wannan Medical College, Wuhu, Anhui, 241000, PR China. Electronic address: zhangchao@wnmc.edu.cn.
Eur J Med Chem ; 245(Pt 1): 114860, 2023 Jan 05.
Article em En | MEDLINE | ID: mdl-36370550
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Espécies Reativas de Oxigênio / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase / Tiorredoxina Redutase 1 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Espécies Reativas de Oxigênio / Inibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenase / Tiorredoxina Redutase 1 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article