Gambogic acid and juglone inhibit RNase P through distinct mechanisms.

Wu Meyers, Nancy; Karasik, Agnes; Kaitany, Kipchumba; Fierke, Carol A; Koutmos, Markos

Wu Meyers, Nancy; Karasik, Agnes; Kaitany, Kipchumba; Fierke, Carol A; Koutmos, Markos.

Afiliação

Wu Meyers N; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA.
Karasik A; Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Kaitany K; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA.
Fierke CA; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: carolfierke@brandeis.edu.
Koutmos M; Program in Chemical Biology, University of Michigan, Ann Arbor, Michigan, USA; Department of Chemistry, University of Michigan, Ann Arbor, Michigan, USA; Program in Biophysics, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: mkoutmos@umich.edu.

J Biol Chem ; 298(12): 102683, 2022 12.

Article em En | MEDLINE | ID: mdl-36370850

Assuntos

Naftoquinonas; Ribonuclease P; Humanos; Arabidopsis/metabolismo; Proteínas de Arabidopsis/antagonistas & inibidores; Proteínas de Arabidopsis/metabolismo; Naftoquinonas/farmacologia; Ribonuclease P/antagonistas & inibidores; Ribonuclease P/metabolismo; Precursores de RNA/metabolismo; RNA de Transferência/metabolismo

Palavras-chave

RNase P; X-ray crystallography; inhibition mechanism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Naftoquinonas / Ribonuclease P Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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