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M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Dwomoh, Louis; Rossi, Mario; Scarpa, Miriam; Khajehali, Elham; Molloy, Colin; Herzyk, Pawel; Mistry, Shailesh N; Bottrill, Andrew R; Sexton, Patrick M; Christopoulos, Arthur; Conn, Jeffrey; Lindsley, Craig W; Bradley, Sophie J; Tobin, Andrew B.
Afiliação
  • Dwomoh L; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Rossi M; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Scarpa M; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Khajehali E; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Molloy C; Department of Anatomy and Physiology, School of Biomedical Sciences, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3010, Australia.
  • Herzyk P; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Mistry SN; Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.
  • Bottrill AR; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
  • Sexton PM; Research Technology Platforms, University of Warwick, School of Life Sciences, Coventry CV4 7AL, UK.
  • Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Conn J; Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Lindsley CW; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Bradley SJ; Australian Research Council Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
  • Tobin AB; Warren Centre for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, USA.
Sci Signal ; 15(760): eabm3720, 2022 11 15.
Article em En | MEDLINE | ID: mdl-36378750
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Doenças Priônicas / Doenças Neurodegenerativas / Doença de Alzheimer Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Príons / Doenças Priônicas / Doenças Neurodegenerativas / Doença de Alzheimer Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article