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Tirucallane-type triterpenoid from the stem bark of Chisocheton lasiocarpus and its cytotoxic activity against MCF-7 breast cancer cells.
Parulian, Samuel San; Naini, Al Arofatus; Hilmayanti, Erina; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; Maharani, Rani; Herlina, Tati; Supratman, Unang; Anwar, Risyandi; Fajriah, Sofa; Azmi, Mohamad Nurul; Prescott, Thomas; Shiono, Yoshihito.
Afiliação
  • Nurlelasari; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Parulian SS; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Naini AA; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Hilmayanti E; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Farabi K; Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka 560-0043, Japan.
  • Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Darwati; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Mayanti T; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Maharani R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Herlina T; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Supratman U; Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Anwar R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Fajriah S; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Azmi MN; Central Laboratory, Universitas Padjadjaran, Jatinangor 45363, Indonesia.
  • Prescott T; Herbal Medicine Research, Department of Pediatric Dentistry, Faculty of Dental Medicine, University of Muhammadiyah Semarang, Semarang 50272, Indonesia.
  • Shiono Y; Research Center for Chemistry, National Research and Innovation Agency (BRIN) Kawasan PUSPIPTEK Serpong Tangeran Selatan, Banten 15314, Indonesia.
J Asian Nat Prod Res ; 25(8): 803-809, 2023.
Article em En | MEDLINE | ID: mdl-36409205
ABSTRACT
Chisocarpene A (1) is a new tirucallane-type triterpenoid together with odoratone (2) and 24-methylenecycloartanol (3), isolated from the stem bark of Chisocheton lasiocarpus. The chemical structures of compounds 1-3 were elucidated through a detailed analysis of their spectroscopic data (IR, MS, 1 D, and 2 D NMR). The isolated compounds were evaluated for cytotoxic activity against the MCF-7 breast cancer cell line using a resazurin-based assay. Compound 1 showed the most potent activity (IC50 26.56 ± 1.01 µM) and was two-fold more active than the positive control.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article