Discovery and optimization of 2-(trifluoromethyl)benzimidazole derivatives as novel ferroptosis inducers in vitro and in vivo.

Fang, Yuying; Tan, Qingyun; Zhou, Huihao; Xu, Jun; Gu, Qiong

Fang, Yuying; Tan, Qingyun; Zhou, Huihao; Xu, Jun; Gu, Qiong.

Afiliação

Fang Y; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen, University, Guangzhou, 510006, China.
Tan Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen, University, Guangzhou, 510006, China.
Zhou H; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen, University, Guangzhou, 510006, China.
Xu J; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen, University, Guangzhou, 510006, China. Electronic address: xujun9@mail.sysu.edu.cn.
Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen, University, Guangzhou, 510006, China. Electronic address: guqiong@mail.sysu.edu.cn.

Eur J Med Chem ; 245(Pt 1): 114905, 2023 Jan 05.

Article em En | MEDLINE | ID: mdl-36410168

Assuntos

Ferroptose; Neoplasias Hepáticas; Humanos; Antinematódeos; Benzimidazóis/farmacologia; Ácido Glutâmico

Palavras-chave

Anti-cancer; Ferroptosis inducer; Structural modification; System X(c)(−)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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