PROTAC therapy as a new targeted therapy for lung cancer.

Li, Jennifer W; Zheng, Guangrong; Kaye, Frederic J; Wu, Lizi

Li, Jennifer W; Zheng, Guangrong; Kaye, Frederic J; Wu, Lizi.

Afiliação

Li JW; Department of Medicine, Brown University, Providence, RI 02912, USA.
Zheng G; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA; UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA.
Kaye FJ; UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA; Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA; UF Genetics Institute, University of Florida, Gainesville, FL 32610, USA. Electronic address: fkaye@ufl.edu.
Wu L; UF Health Cancer Center, University of Florida, Gainesville, FL 32610, USA; UF Genetics Institute, University of Florida, Gainesville, FL 32610, USA; Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA. Electronic address: lzwu@uf

Mol Ther ; 31(3): 647-656, 2023 03 01.

Article em En | MEDLINE | ID: mdl-36415148

Assuntos

Neoplasias Pulmonares; Complexo de Endopeptidases do Proteassoma; Humanos; Complexo de Endopeptidases do Proteassoma/metabolismo; Proteínas/metabolismo; Proteólise; Ubiquitina-Proteína Ligases/genética; Neoplasias Pulmonares/tratamento farmacológico; Neoplasias Pulmonares/genética

Palavras-chave

PROTACs; argeted protein degradation; lung cancer; proteolysis targeting chimeras; targeted therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complexo de Endopeptidases do Proteassoma / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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