Enhanced activity of Alzheimer disease-associated variant of protein kinase C&#945; drives cognitive decline in a mouse model.

Lordén, Gema; Wozniak, Jacob M; Doré, Kim; Dozier, Lara E; Cates-Gatto, Chelsea; Patrick, Gentry N; Gonzalez, David J; Roberts, Amanda J; Tanzi, Rudolph E; Newton, Alexandra C

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Lordén, Gema; Wozniak, Jacob M; Doré, Kim; Dozier, Lara E; Cates-Gatto, Chelsea; Patrick, Gentry N; Gonzalez, David J; Roberts, Amanda J; Tanzi, Rudolph E; Newton, Alexandra C.

Afiliação

Lordén G; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Wozniak JM; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Doré K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Dozier LE; Center for Neural Circuits and Behavior, Department of Neurosciences, University of California San Diego, La Jolla, CA, 92093, USA.
Cates-Gatto C; Section of Neurobiology. Division of Biological sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Patrick GN; Animal Models Core Facility, The Scripps Research Institute, La Jolla, CA, 92037, USA.
Gonzalez DJ; Section of Neurobiology. Division of Biological sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Roberts AJ; Department of Pharmacology, University of California San Diego, La Jolla, CA, 92093, USA.
Tanzi RE; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, 92093, USA.
Newton AC; Animal Models Core Facility, The Scripps Research Institute, La Jolla, CA, 92037, USA.

Nat Commun ; 13(1): 7200, 2022 11 23.

Article em En | MEDLINE | ID: mdl-36418293

Assuntos

Doença de Alzheimer; Disfunção Cognitiva; Camundongos; Animais; Doença de Alzheimer/metabolismo; Proteína Quinase C-alfa/genética; Proteína Quinase C-alfa/metabolismo; Disfunção Cognitiva/genética; Modelos Animais de Doenças; Peptídeos beta-Amiloides/metabolismo; Isoenzimas

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Disfunção Cognitiva Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google