COVID-19 vaccination hesitancy and safety among adult people with epilepsy in eastern China.
Epilepsy Behav
; 138: 108984, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36423385
ABSTRACT
OBJECTIVE:
This study assesses the hesitancy and safety of vaccination administration for the novel 2019 Coronavirus Disease (COVID-19) among adult people with epilepsy (PWE).METHODS:
We recruited adult PWE who visited the outpatient epilepsy clinic from August 2021 to February 2022. We administered a structured questionnaire and a face-to-face interview regarding demographic factors, epilepsy characteristics, and relevant vaccine issues to all patients. Factors related to receiving a vaccine and epilepsy-related events after vaccination were then analyzed.RESULTS:
A total of 501 PWE were surveyed; 288 were unvaccinated and 213 were vaccinated. Patients without jobs (OR 0.59; 95% CI 0.37-0.95, p = 0.03) were less likely to receive the vaccine compared to students or those with jobs. Other factors associated with vaccination were a higher number of anti-seizure medications (OR 0.72; 95% CI 0.55-0.95, p = 0.02) and a lower pre-vaccine seizure frequency (OR 2.21; 95% CI 1.06-4.59, p = 0.03). Of the 213 vaccinated patients, 10 (4.70%) reported at least one local and/or systemic side effect. Most patients (92.50%) did not report worse seizures within one month of vaccination. Poor ASM adherence (OR 15.06; 95% CI 1.75-129.87, p = 0.01) and fatigue/stimulant drinks such as caffeine (OR 50.59; 95% CI 7.57-337.94, p < 0.01) were significantly associated with seizure worsening within one month of receiving the COVID-19 vaccination.CONCLUSION:
Almost two-fifths of patients with adult PWE have received a COVID-19 vaccine. Attention should be paid to educating epilepsy patients without jobs on the significance and safety of the vaccine. There was a low risk of seizure worsening in the short term after vaccination in PWE.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Epilepsia
/
Vacinas contra COVID-19
/
COVID-19
Tipo de estudo:
Qualitative_research
Limite:
Adult
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article